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Sulfamethoxazole/Trimethoprim for Fish (Fish Sulfa)

Sulfonamide combination antibiotic ยท Updated 2026-09-30

Quick answerSulfamethoxazole and trimethoprim block two consecutive steps bacteria need to make folate. Used together they are more effective than either drug alone. Broad, with activity against many gram-positive and gram-negative bacteria.

What sulfamethoxazole/trimethoprim is commonly used for

  • General bacterial infections
  • Fin rot and ulcers
  • Backup option when a first antibiotic class has not worked

Things to know

  • People with sulfa allergies should avoid contact with the tablets and treated water.
  • Not effective against parasites or fungi.
  • Treat in a hospital tank where possible.

How it compares with other options

Sulfamethoxazole/Trimethoprim is one of several classes of antibiotic used by keepers. Our comparison guide lays out which class suits which problem, and our treatment packs combine complementary classes so you have a backup ready.

Products containing sulfamethoxazole/trimethoprim

Sulfamethoxazole/Trimethoprim FAQ

What does the 960mg on Fish Sulfa mean?

It refers to the combined strength of the sulfamethoxazole and trimethoprim in each tablet. Follow the directions on the label for how much to use.

Responsible use. For ornamental aquarium fish only. Not for human use or fish intended for food. Follow the label and consult a veterinarian when unsure.